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FP7 ERA-NET on
Nanosafety Safe Implementation of Innovative Nanoscience and Nanotechnology |
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 | The use of
manufactured nanomaterials (MNM) in particulate form is increasing
steadily, but little is known about their fate and effects after
release into the airborne state and subsequent deposition in the
respiratory tract. Especially the influence of matrix effects in liquid
formulations on MNM fate, e.g. their ability to absorb other substances
and serving as a carrier to otherwise inaccessible sites in the lungs
of organisms still remains to be investigated. Toxicological properties
of MNM are determined by short term aging processes in daily life
scenarios, which are unknown to a large extent. The project NANOaers combines physicochemical and toxicological in vitro - 3D cell models and precision cut lung slices (PCLS) - and in vivo experiments with modelling approach. This widespread approach is used to identify essential parameters for determining the fate and short and long-term effects of MNM after aerosolization of formulations as a basis for further regulatory and normative needs. |
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This project is part
of the SIINN ERA-NET and is funded under the ERA-NET scheme of the Seventh Framework Programme of the European Commission, Research Directorate - General, Grant Agreement No. 265799 |
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